Structure of PDB 1zxv Chain B

Receptor sequence
>1zxvB (length=736) Species: 1392 (Bacillus anthracis) [Search protein sequence]
ERNKTQEEHLKEIMKHIVKIEVKGEEAVKKEAAEKLLEKVPSDVLEMYKA
IGGKIYIVDGDITKHISLEALSEDKKKIKDIYGKDALLHEHYVYAKEGYE
PVLVIQSSEDYVENTEKALNVYYEIGKILSRDILSKINQPYQKFLDVLNT
IKNASDSDGQDLLFTNQLKEHPTDFSVEFLEQNSNEVQEVFAKAFAYYIE
PQHRDVLQLYAPEAFNYMDKFNEQEINLSLEELKDQRMLSRYEKWEKIKQ
HYQHWSDSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQEEKELLKRIQIDS
SDFLSTEEKEFLKKLQIDIRDSDSSNPLSEKEKEFLKKLKLDIQPYDINQ
RLQDTGGLIDSPSINLDVRKQYKRDIQNIDALLHQSIGSTLYNKIYLYEN
MNINNLTATLGADLVDSTDNTKINRGIFNEFKKNFKYSISSNYMIVDINE
RPALDNERLKWRIQLSPDTRAGYLENGKLILQRNIGLEIKDVQIIKQSEK
EYIRIDAKVVPKSKIDTKIQEAQLNINQEWNKALGLPKYTKLITFNVHNR
YASNIVESAYLILNEWKNNIQSDLIKKVTNYLVDGNGRFVFTDITLPNIA
EQYTHQDEIYEQVHSKGLYVPESRSILLHGPSKGVELRNDSEGFIHEFGH
AVDDYAGYLLDKNQSDLVTNSKKFIDIFKEEGSNLTSYGRTNEAEFFAEA
FRLMHSTDHAERLKVQKNAPKTFQFINDQIKFIINS
3D structure
PDB1zxv Efficient synthetic inhibitors of anthrax lethal factor.
ChainB
Resolution2.67 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H686 E687 H690 Y728 E735
Catalytic site (residue number reindexed from 1) H646 E647 H650 Y688 E695
Enzyme Commision number 3.4.24.83: anthrax lethal factor endopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H686 H690 E735 H646 H650 E695
BS02 MFM B S655 G657 L658 P661 E687 H690 Y728 S615 G617 L618 P621 E647 H650 Y688 BindingDB: IC50=1700nM,Ki=800nM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008237 metallopeptidase activity
GO:0046872 metal ion binding
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Cellular Component
External links
PDB RCSB:1zxv, PDBe:1zxv, PDBj:1zxv
PDBsum1zxv
PubMed15983377
UniProtQ52NH3

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