Structure of PDB 1zxi Chain B

Receptor sequence

>1zxiB (length=804) Species: 504832 (Afipia carboxidovorans OM5)

TVEPTSAERAEKLQGMGCKRKRVEDIRFTQGKGNYVDDVKLPGMLFGDFV
RSSHAHARIKSIDTSKAKALPGVFAVLTAADLKPLNLHYMPTLAGDVQAV
LADEKVLFQNQEVAFVVAKDRYVAADAIELVEVDYEPLPVLVDPFKAMEP
DAPLLREDIKDKMTGAHGARKHHNHIFRWEIGDKEGTDATFAKAEVVSKD
MFTYHRVHPSPLETCQCVASMDKIKGELTLWGTFQAPHVIRTVVSLISGL
PEHKIHVIAPDIGGGFGNKVGAYSGYVCAVVASIVLGVPVKWVEDRMENL
STTSFARDYHMTTELAATKDGKILAMRCHVLADHGAFDACADPSKWPAGF
MNICTGSYDMPVAHLAVDGVYTNKASGGVAYRCSFRVTEAVYAIERAIET
LAQRLEMDSADLRIKNFIQPEQFPYMAPLGWEYDSGNYPLAMKKAMDTVG
YHQLRAEQKAKQEAFKRGETREIMGIGISFFTEIVGAGPSKNCDILGVSM
FDSAEIRIHPTGSVIARMGTKSQGQGHETTYAQIIATELGIPADDIMIEE
GNTDTAPYGLGTYGSRSTPTAGAATAVAARKIKAKAQMIAAHMLEVHEGD
LEWDVDRFRVKGLPEKFKTMKELAWASYNSPPPNLEPGLEAVNYYDPPNM
TYPFGAYFCIMDIDIDTGVAKTRRFYALDDCGTRINPMIIEGQVHGGLTE
AFAVAMGQEIRYDEQGNVLGASFMDFFLPTAVETPKWETDYTVTPSPHHP
IGAKGVGESPHVGGVPCFSNAVNDAYAFLNAGHIQMPHDAWRLWKVGEQL
GLHV

3D structure

• PDB: 1zxi Structural and functional reconstruction in situ of the [CuSMoO(2)] active site of carbon monoxide dehydrogenase from the carbon monoxide oxidizing eubacterium Oligotropha carboxidovorans
• Chain: B
• Resolution: 1.7 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): Q240 V275 P352 I358 R387 C388 E763 S764
• Catalytic site (residue number reindexed from 1): Q235 V270 P347 I353 R382 C383 E758 S759
• Enzyme Commision number: 1.2.5.3: aerobic carbon monoxide dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CU	B	C388 S389 E763	C383 S384 E758
BS02	CUM	B	F271 G272 A385 Y386 R387 C388 Y568 G569 E763	F266 G267 A380 Y381 R382 C383 Y563 G564 E758
BS03	MCN	B	G270 F271 R387 Q528 G529 Q530 H532 T535 T567 Y568 S570 S572 T573 C686 I690 I694 I695 Q698 K759 G760 V761 E763	G265 F266 R382 Q523 G524 Q525 H527 T530 T562 Y563 S565 S567 T568 C681 I685 I689 I690 Q693 K754 G755 V756 E758

Gene Ontology

Molecular Function

• GO:0005506 iron ion binding
• GO:0005507 copper ion binding
• GO:0008805 carbon-monoxide oxygenase activity
• GO:0016491 oxidoreductase activity
• GO:0030151 molybdenum ion binding
• GO:0043885 anaerobic carbon-monoxide dehydrogenase activity
• GO:0046872 metal ion binding

External links

• PDB: RCSB:1zxi, PDBe:1zxi, PDBj:1zxi
• PDBsum: 1zxi
• PubMed: 16091936
• UniProt: P19919|DCML_AFIC5 Carbon monoxide dehydrogenase large chain (Gene Name=coxL)