Structure of PDB 1zsn Chain B

Receptor sequence

>1zsnB (length=292) Species: 5833 (Plasmodium falciparum) [Search protein sequence]

EDICFIAGIGDTNGYGWGIAKELSKRNVKIIFGIWPPVYNIFMKNYKNGK
FDNDMIIDKDKKMNILDMLPFDASFDTANDIDEETKNNKRYNMLQNYTIE
DVANLIHQKYGKINMLVHSLANAKEVQKDLLNTSRKGYLDALSKSSYSLI
SLCKYFVNIMKPQSSIISLTYHASQKVVPGYGGGMSSAKAALESDTRVLA
YHLGRNYNIRINTISAGPLKSRAATAINYTFIDYAIEYSEKYAPLRQKLL
STDIGSVASFLLSRESRAITGQTIYVDNGLNIMFLPDDIYRN

3D structure

PDB

1zsn Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-Substituted triclosan derivatives.

Chain

Resolution

2.992 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	Y277 K285
Catalytic site (residue number reindexed from 1)	Y181 K189
Enzyme Commision number	1.3.1.9: enoyl-[acyl-carrier-protein] reductase (NADH).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	B	G106 G110 Y111 W131 D168 A169 S215 L216 N218 L265 T266 Y267 K285 A312 P314 L315 S317 A319	G10 G14 Y15 W35 D72 A73 S119 L120 N122 L169 T170 Y171 K189 A216 P218 L219 S221 A223
BS02	TN2	B	A217 N218 A219 V222 Y267 Y277 M281 A319 I323	A121 N122 A123 V126 Y171 Y181 M185 A223 I227

Gene Ontology

	Molecular Function
GO:0004318	enoyl-[acyl-carrier-protein] reductase (NADH) activity

	Biological Process
GO:0006633	fatty acid biosynthetic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:1zsn, PDBe:1zsn, PDBj:1zsn
PDBsum	1zsn
PubMed	16198563
UniProt	Q9BH77

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