Structure of PDB 1zky Chain B

Receptor sequence
>1zkyB (length=245) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILL
NSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRL
AQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRL
3D structure
PDB1zky Identification of ligands with bicyclic scaffolds provides insights into mechanisms of estrogen receptor subtype selectivity.
ChainB
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 K362 L372 V376 E380 L539 E542 I54 K58 L68 V72 E76 L235 E238
BS02 689 B E353 L387 F404 M421 G521 H524 E49 L83 F100 M117 G217 H220 MOAD: Ki=560nM
External links
PDB RCSB:1zky, PDBe:1zky, PDBj:1zky
PDBsum1zky
PubMed16648639
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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