Structure of PDB 1zbh Chain B

Receptor sequence
>1zbhB (length=225) Species: 9606 (Homo sapiens) [Search protein sequence]
DSYYDYICIIDFEATCEEGNPPEFVHEIIEFPVVLLNTHTLEIEDTFQQY
VRPEINTQLSDFCISLTGITQDQVDRADTFPQVLKKVIDLMKLKELGTKY
KYSLLTDGSWDMSKFLNIQCQLSRLKYPPFAKKWINIRKSYGNFYKVPRS
QTKLTIMLEKLGMDYDGRPNCGLDDSKNIARIAVRMLQDGCELRINEKMH
AGQLMSVSSSLPIEGTPPPQMPHFR
3D structure
PDB1zbh Structural basis for 3'-end specific recognition of histone mRNA stem-loop by 3'-exonuclease, a human nuclease that also targets siRNA
ChainB
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D134 D234 D298
Catalytic site (residue number reindexed from 1) D11 D111 D175
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B D134 E136 D298 D11 E13 D175
BS02 AMP B D134 E136 A137 C139 N143 F185 L189 F238 D11 E13 A14 C16 N20 F62 L66 F115
Gene Ontology
Molecular Function
GO:0000175 3'-5'-RNA exonuclease activity
GO:0003676 nucleic acid binding

View graph for
Molecular Function
External links
PDB RCSB:1zbh, PDBe:1zbh, PDBj:1zbh
PDBsum1zbh
PubMed
UniProtQ8IV48|ERI1_HUMAN 3'-5' exoribonuclease 1 (Gene Name=ERI1)

[Back to BioLiP]