Structure of PDB 1z8j Chain B

Receptor sequence
>1z8jB (length=243) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHRNIEKISMLEKIYIHPRYNWRENLDRDIALMKLK
KPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETQPSVLQVVN
LPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEPDSGGPFVMKSP
FNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
3D structure
PDB1z8j Energetic and structural consequences of perturbing Gly-193 in the oxyanion hole of serine proteases
ChainB
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 P193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 D93 E188 P189 D190 S191 G192
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0G6 B H57 L99 D189 A190 S195 S214 W215 G216 H43 L90 D185 A186 S191 S212 W213 G214
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1z8j, PDBe:1z8j, PDBj:1z8j
PDBsum1z8j
PubMed15890651
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

[Back to BioLiP]