Structure of PDB 1yxm Chain B

Receptor sequence
>1yxmB (length=283) Species: 9606 (Homo sapiens) [Search protein sequence]
RSYLAPGLLQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKS
AADELQANLPPTKQARVIPIQCNIRNEEEVNNLVKSTLDTFGKINFLVNN
GGGQFLSPAEHISSKGWHAVLETNLTGTFYMCKAVYSSWMKEHGGSIVNI
IVPTKAGFPLAVHSGAARAGVYNLTKSLALEWACSGIRINCVAPGVIYSQ
TAQSFFEGSFQKIPAKRIGVPEEVSSVVCFLLSPAASFITGQSVDVDGGR
SLYTHSYEVPDHDNWPKGAGDLSVVKKMKETFK
3D structure
PDB1yxm Crystal structure of perixomal trans 2-enoyl CoA reductase (PECRA)
ChainB
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G29 V159 G164 H170 S171 R175
Catalytic site (residue number reindexed from 1) G22 V152 G157 H163 S164 R168
Enzyme Commision number 1.3.1.38: trans-2-enoyl-CoA reductase (NADPH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADE B S49 R50 C79 N80 I81 T130 S42 R43 C72 N73 I74 T123
Gene Ontology
Molecular Function
GO:0005102 signaling receptor binding
GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0033306 phytol metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1yxm, PDBe:1yxm, PDBj:1yxm
PDBsum1yxm
PubMed
UniProtQ9BY49|PECR_HUMAN Peroxisomal trans-2-enoyl-CoA reductase (Gene Name=PECR)

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