Structure of PDB 1ys4 Chain B

Receptor sequence
>1ys4B (length=348) Species: 2190 (Methanocaldococcus jannaschii) [Search protein sequence]
MKIKVGVLGATGSVGQRFVQLLADHPMFELTALAASERSAGKKYKDACYW
FQDRDIPENIKDMVVIPTDPKHEEFEDVDIVFSALPSDLAKKFEPEFAKE
GKLIFSNASAYRMEEDVPLVIPEVNADHLELIEIQREKRGWDGAIITNPN
CSTICAVITLKPIMDKFGLEAVFIATMQAVSGAGYNGVPSMAILDNLIPF
IKNEEEKMQTESLKLLGTLKDGKVELANFKISASCNRVAVIDGHTESIFV
KTKEGAEPEEIKEVMDKFDPLKDLNLPTYAKPIVIREEIDRPQPRLDRNE
GNGMSIVVGRIRKDPIFDVKYTALEHNTIRGAAGASVLNAEYFVKKYI
3D structure
PDB1ys4 A New Branch in the Family: Structure of Aspartate-beta-semialdehyde Dehydrogenase from Methanococcus jannaschii
ChainB
Resolution2.29 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.2.1.11: aspartate-semialdehyde dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP B G15 T17 G18 V20 A41 S42 S45 P92 L95 N113 G188 N333 T334 A338 G9 T11 G12 V14 A35 S36 S39 P86 L89 N107 G182 N327 T328 A332
Gene Ontology
Molecular Function
GO:0004073 aspartate-semialdehyde dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0046983 protein dimerization activity
GO:0050661 NADP binding
GO:0051287 NAD binding
Biological Process
GO:0006520 amino acid metabolic process
GO:0008652 amino acid biosynthetic process
GO:0009085 lysine biosynthetic process
GO:0009086 methionine biosynthetic process
GO:0009088 threonine biosynthetic process
GO:0009089 lysine biosynthetic process via diaminopimelate
GO:0009097 isoleucine biosynthetic process
GO:0019877 diaminopimelate biosynthetic process
GO:0071266 'de novo' L-methionine biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1ys4, PDBe:1ys4, PDBj:1ys4
PDBsum1ys4
PubMed16225889
UniProtQ57658|DHAS_METJA Aspartate-semialdehyde dehydrogenase (Gene Name=asd)

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