Structure of PDB 1ygu Chain B

Receptor sequence

>1yguB (length=582) Species: 9606 (Homo sapiens)

KQLMNVEPIHADILLETYKRKIADEGRPFLAEFQSIPRVFSKFPIKEARK
PFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIA
AQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTR
AFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGV
PEDPHLLLKLRRRVNAFSNFFSGPIVVHSSAGVGRTGTYIGIDAMLEGLE
AENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSE
LHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRN
SNVIPYDYNRVPLKHESKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQ
MIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSST
YTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKL
PQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIF
QVVKALRKARLGMVSTFEQYQFLYDVIASTYP

3D structure

• PDB: 1ygu Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45.
• Chain: B
• Resolution: 2.9 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D796 S828 R834 T835 Q872
• Catalytic site (residue number reindexed from 1): D197 S229 R235 T236 Q273
• Enzyme Commision number: 3.1.3.48: protein-tyrosine-phosphatase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	R657 Y658 D660 H797 S828 S829 A830 V832 G833 R834 Q872	R58 Y59 D61 H198 S229 S230 A231 V233 G234 R235 Q273

Gene Ontology

Molecular Function

• GO:0004725 protein tyrosine phosphatase activity

Biological Process

• GO:0006470 protein dephosphorylation
• GO:0016311 dephosphorylation

External links

• PDB: RCSB:1ygu, PDBe:1ygu, PDBj:1ygu
• PDBsum: 1ygu
• PubMed: 15684325
• UniProt: P08575|PTPRC_HUMAN Receptor-type tyrosine-protein phosphatase C (Gene Name=PTPRC)