Structure of PDB 1y25 Chain B

Receptor sequence
>1y25B (length=165) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
HSQITLRGNAINTVGELPAVGSPAPAFTLTGGDLGVISSDQFRGKSVLLN
IFPSVDTPVSATSVRTFDERAAASGATVLCVSKDLPFAQKRFCGAEGTEN
VMPASAFRDSFGEDYGVTIADGPMAGLLARAIVVIGADGNVAYTELVPEI
AQEPNYEAALAALGA
3D structure
PDB1y25 Structure of the inactive variant C60S of Mycobacterium tuberculosis thiol peroxidase
ChainB
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.11.1.24: thioredoxin-dependent peroxiredoxin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACT B T57 P58 V59 S60 R130 T57 P58 V59 S60 R130
Gene Ontology
Molecular Function
GO:0004601 peroxidase activity
GO:0005515 protein binding
GO:0008379 thioredoxin peroxidase activity
GO:0015036 disulfide oxidoreductase activity
GO:0016209 antioxidant activity
GO:0016491 oxidoreductase activity
GO:0016684 oxidoreductase activity, acting on peroxide as acceptor
GO:0051920 peroxiredoxin activity
GO:0140824 thioredoxin-dependent peroxiredoxin activity
Biological Process
GO:0006979 response to oxidative stress
GO:0045454 cell redox homeostasis
GO:0051409 response to nitrosative stress
GO:0098754 detoxification
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005576 extracellular region
GO:0005829 cytosol
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1y25, PDBe:1y25, PDBj:1y25
PDBsum1y25
PubMed16627951
UniProtP9WG35|TPX_MYCTU Thiol peroxidase (Gene Name=tpx)

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