Structure of PDB 1xxx Chain B

Receptor sequence
>1xxxB (length=295) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
FDVAARLGTLLTAMVTPFSGDGSLDTATAARLANHLVDQGCDGLVVSGTT
GESPTTTDGEKIELLRAVLEAVGDRARVIAGAGTYDTAHSIRLAKACAAE
GAHGLLVVTPYYSKPPQRGLQAHFTAVADATELPMLLYDIPGRSAVPIEP
DTIRALASHPNIVGVKDAKADLHSGAQIMADTGLAYYSGDDALNLPWLAM
GATGFISVIAHLAAGQLRELLSAFGSGDIATARKINIAVAPLCNAMSRLG
GVTLSKAGLRLQGIDVGDPRLPQVAATPEQIDALAADMRAASVLR
3D structure
PDB1xxx Crystal structure and kinetic study of dihydrodipicolinate synthase from Mycobacterium tuberculosis.
ChainB
Resolution2.28 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T54 Y117 Y143 R148 K171 I211
Catalytic site (residue number reindexed from 1) T49 Y112 Y138 R143 K166 I206
Enzyme Commision number 4.3.3.7: 4-hydroxy-tetrahydrodipicolinate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B A162 H164 I167 A157 H159 I162
Gene Ontology
Molecular Function
GO:0008840 4-hydroxy-tetrahydrodipicolinate synthase activity
GO:0016829 lyase activity
Biological Process
GO:0009085 lysine biosynthetic process
GO:0009089 lysine biosynthetic process via diaminopimelate
GO:0019877 diaminopimelate biosynthetic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1xxx, PDBe:1xxx, PDBj:1xxx
PDBsum1xxx
PubMed18062777
UniProtP9WP25|DAPA_MYCTU 4-hydroxy-tetrahydrodipicolinate synthase (Gene Name=dapA)

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