Structure of PDB 1xrj Chain B

Receptor sequence
>1xrjB (length=213) Species: 9606 (Homo sapiens) [Search protein sequence]
EPFLIGVSGGTASGKSSVCAKIVQLLGQNEVDYRQKQVVILSQDSFYRVL
TSEQKAKALKGQFNFDHPDAFDNELILKTLKEITEGKTVQIPVYDFVSHS
RKEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVL
RDISERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIPRGADNLVAI
NLIVQHIQDILNG
3D structure
PDB1xrj Structure of human uridine-cytidine kinase 2 determined by SIRAS using a rotating-anode X-ray generator and a single samarium derivative.
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.48: uridine/cytidine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B S60 D62 E135 S42 D44 E117
BS02 C5P B T29 Y65 F83 D84 Y112 F114 H117 R166 R169 R174 R176 Q184 T11 Y47 F65 D66 Y94 F96 H99 R148 R151 R156 R158 Q166
BS03 ADP B A30 S31 G32 K33 S34 S35 R165 R169 D213 A12 S13 G14 K15 S16 S17 R147 R151 D195
Gene Ontology
Molecular Function
GO:0004849 uridine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0042802 identical protein binding
GO:0043771 cytidine kinase activity
Biological Process
GO:0009224 CMP biosynthetic process
GO:0016310 phosphorylation
GO:0044206 UMP salvage
GO:0044211 CTP salvage
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1xrj, PDBe:1xrj, PDBj:1xrj
PDBsum1xrj
PubMed15735337
UniProtQ9BZX2|UCK2_HUMAN Uridine-cytidine kinase 2 (Gene Name=UCK2)

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