Structure of PDB 1xdd Chain B

Receptor sequence

>1xddB (length=182) Species: 9606 (Homo sapiens) [Search protein sequence]

GNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSY
KTEFDFSDYVKWKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGAR
PDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKF
ASKPASEFVKILDTFEKLKDLFTELQKKIYVI

3D structure

PDB

1xdd Improved lymphocyte function-associated antigen-1 (LFA-1) inhibition by statin derivatives: molecular basis determined by x-ray analysis and monitoring of LFA-1 conformational changes in vitro and ex vivo

Chain

Resolution

2.2 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	AAY	B	Q303 K304	Q176 K177	MOAD: ic50=0.2uM
BS02	MG	B	S139 S141 D239	S12 S14 D112
BS03	AAY	B	I235 Y257 E301	I108 Y130 E174	MOAD: ic50=0.2uM

External links

PDB	RCSB:1xdd, PDBe:1xdd, PDBj:1xdd
PDBsum	1xdd
PubMed	15304496
UniProt	P20701\|ITAL_HUMAN Integrin alpha-L (Gene Name=ITGAL)

[Back to BioLiP]