Structure of PDB 1x78 Chain B

Receptor sequence
>1x78B (length=228) Species: 9606 (Homo sapiens) [Search protein sequence]
LSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISW
AKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVL
DRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMDS
SRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKG
MEHLLNMKCKNVVPVYDLLLEMLNAHVL
3D structure
PDB1x78 Structure-Based Design of Estrogen Receptor-Beta Selective Ligands
ChainB
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I310 K314 E493 I48 K52 E221
BS02 244 B E305 L339 I376 F377 G472 H475 L476 E43 L77 I114 F115 G200 H203 L204 MOAD: ic50=14nM
BindingDB: IC50=14nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:1x78, PDBe:1x78, PDBj:1x78
PDBsum1x78
PubMed15548008
UniProtQ92731|ESR2_HUMAN Estrogen receptor beta (Gene Name=ESR2)

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