Structure of PDB 1x27 Chain B

Receptor sequence
>1x27B (length=164) Species: 9606 (Homo sapiens) [Search protein sequence]
MNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIP
FNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGS
FSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNA
SDGLCTRLSRPCQT
3D structure
PDB1x27 Molecular basis for regulation of Src by the docking protein p130Cas
ChainB
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B R134 R154 S156 E157 S158 S164 K179 H180 Y181 K182 I193 S194 R196 G215 R72 R92 S94 E95 S96 S102 K117 H118 Y119 K120 I131 S132 R134 G153
External links
PDB RCSB:1x27, PDBe:1x27, PDBj:1x27
PDBsum1x27
PubMed16245368
UniProtP06239|LCK_HUMAN Tyrosine-protein kinase Lck (Gene Name=LCK)

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