Structure of PDB 1wsv Chain B

Receptor sequence

>1wsvB (length=371) Species: 9606 (Homo sapiens)

VLRRTPLYDFHLAHGGKMVAFAGWSLPVQYRDSHTDSHLHTRQHCSLFDV
SHMLQTKILGSDRVKLMESLVVGDIAELRPNQGTLSLFTNEAGGILDDLI
VTNTSEGHLYVVSNAGCWEKDLALMQDKVRELQNQGRDVGLEVLDNALLA
LQGPTAAQVLQAGVADDLRKLPFMTSAVMEVFGVSGCRVTRCGYTGEDGV
EISVPVAGAVHLATAILKNPEVKLAGLAARDSLRLEAGLCLYGNDIDEHT
TPVEGSLSWTLGKRRRAAMDFPGAKVIVPQLKGRVQRRRVGLMCEGAPMR
AHSPILNMEGTKIGTVTSGCPSPSLKKNVAMGYVPCEYSRPGTMLLVEVR
RKQQMAVVSKMPFVPTNYYTL

3D structure

• PDB: 1wsv Crystal Structure of Human T-protein of Glycine Cleavage System at 2.0A Resolution and its Implication for Understanding Non-ketotic Hyperglycinemia
• Chain: B
• Resolution: 2.6 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D101
• Catalytic site (residue number reindexed from 1): D98
• Enzyme Commision number: 2.1.2.10: aminomethyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	THH	B	M56 L88 D101 I103 V115 F176 G196 Y197 E204 Y371	M53 L85 D98 I100 V112 F173 G193 Y194 E201 Y368

Gene Ontology

Molecular Function

• GO:0004047 aminomethyltransferase activity
• GO:0008483 transaminase activity

Biological Process

• GO:0006546 glycine catabolic process
• GO:0019464 glycine decarboxylation via glycine cleavage system

Cellular Component

• GO:0005654 nucleoplasm
• GO:0005739 mitochondrion
• GO:0005759 mitochondrial matrix
• GO:0005960 glycine cleavage complex

External links

• PDB: RCSB:1wsv, PDBe:1wsv, PDBj:1wsv
• PDBsum: 1wsv
• PubMed: 16051266
• UniProt: P48728|GCST_HUMAN Aminomethyltransferase, mitochondrial (Gene Name=AMT)