Structure of PDB 1wnb Chain B

Receptor sequence
>1wnbB (length=474) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
MQHKLLINGELVSGEGEKQPVYNPATGDVLLEIAEASAEQVDAAVRAADA
AFAEWGQTTPKVRAECLLKLADVIEENGQVFAELESRNCGKPLHSAFNDE
IPAIVDVFRFFAGAARCLNGLAAGEYLEGHTSMIRRDPLGVVASIAPWNY
PLMMAAWKLAPALAAGNCVVLKPSEITPLTALKLAELAKDIFPAGVVNIL
FGRGKTVGDPLTGHPKVRMVSLTGSIATGEHIISHTASSIKRTHMELGGK
APVIVFDDADIEAVVEGVRTFGYYNAGQDCTAACRIYAQKGIYDTLVEKL
GAAVATLKSGAPDDESTELGPLSSLAHLERVGKAVEEAKATGHIKVITGG
EKRKGNGYYYAPTLLAGALQDDAIVQKEVFGPVVSVTPFDNEEQVVNWAN
DSQYGLASSVWTKDVGRAHRVSARLQYGCTWVNTHFMLVSEMPHGGQKLS
GYGKDMSLYGLEDYTVVRHVMVKH
3D structure
PDB1wnb Crystal Structure and Kinetics Identify Escherichia coli YdcW Gene Product as a Medium-chain Aldehyde Dehydrogenase
ChainB
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N149 K172 E246 C280 E378 D455
Catalytic site (residue number reindexed from 1) N149 K172 E246 C280 E378 D455
Enzyme Commision number 1.2.1.-
1.2.1.19: aminobutyraldehyde dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BTL B D279 F436 L438 D279 F436 L438
BS02 NAI B I145 A146 W148 K172 G204 G208 D209 T223 G224 S225 T228 H231 G248 E378 I145 A146 W148 K172 G204 G208 D209 T223 G224 S225 T228 H231 G248 E378
Gene Ontology
Molecular Function
GO:0004029 aldehyde dehydrogenase (NAD+) activity
GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0019145 aminobutyraldehyde dehydrogenase (NAD+) activity
GO:0042802 identical protein binding
GO:0051287 NAD binding
Biological Process
GO:0009447 putrescine catabolic process
GO:0019477 L-lysine catabolic process
GO:0051289 protein homotetramerization
Cellular Component
GO:0005829 cytosol
GO:0032991 protein-containing complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:1wnb, PDBe:1wnb, PDBj:1wnb
PDBsum1wnb
PubMed15381418
UniProtP77674|ABDH_ECOLI Gamma-aminobutyraldehyde dehydrogenase (Gene Name=patD)

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