Structure of PDB 1wbg Chain B

Receptor sequence
>1wbgB (length=251) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEGQPS
VLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGP
FVMKSPFNNRWYQMGIVSWGEGCRDDGKYGFYTHVFRLKKWIQKVIDQFG
E
3D structure
PDB1wbg Fragment-Based Lead Discovery Using X-Ray Crystallography
ChainB
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 D99 E194 G195 D196 S197 G198
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B F34 L40 L65 R67 R73 T74 Y76 K81 I82 M84 F19 L26 L60 R62 R68 T69 Y71 K77 I78 M80
BS02 L03 B A190 E192 V213 W215 G216 G219 C220 G226 F227 A192 E194 V217 W219 G220 G222 C223 G230 F231 MOAD: ic50=1mM
PDBbind-CN: -logKd/Ki=3.00,IC50=1mM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1wbg, PDBe:1wbg, PDBj:1wbg
PDBsum1wbg
PubMed15658854
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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