Structure of PDB 1w88 Chain B

Receptor sequence
>1w88B (length=324) Species: 1422 (Geobacillus stearothermophilus) [Search protein sequence]
AQMTMVQAITDALRIELKNDPNVLIFGEDVGVNGGVFRATEGLQAEFGED
RVFDTPLAESGIGGLAIGLALQGFRPVPEIQFFGFVYEVMDSICGQMARI
RYRTGGRYHMPITIRSPFGGGVHTPELHSDSLEGLVAQQPGLKVVIPSTP
YDAKGLLISAIRDNDPVIFLEHLKLYRSFRQEVPEGEYTIPIGKADIKRE
GKDITIIAYGAMVHESLKAAAELEKEGISAEVVDLRTVQPLDIETIIGSV
EKTGRAIVVQEAQRQAGIAANVVAEINERAILSLEAPVLRVAAPDTVYPF
AQAESVWLPNFKDVIETAKKVMNF
3D structure
PDB1w88 A Molecular Switch and Proton-Wire Synchronize the Active Sites in Thiamine-Dependent Enzymes
ChainB
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E59 E88 H128
Catalytic site (residue number reindexed from 1) E59 E88 H128
Enzyme Commision number 1.2.4.1: pyruvate dehydrogenase (acetyl-transferring).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TPP B E28 L57 E59 Q81 F85 E28 L57 E59 Q81 F85
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:1w88, PDBe:1w88, PDBj:1w88
PDBsum1w88
PubMed15514159
UniProtP21874|ODPB_GEOSE Pyruvate dehydrogenase E1 component subunit beta (Gene Name=pdhB)

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