Structure of PDB 1w6f Chain B

Receptor sequence
>1w6fB (length=269) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence]
GYLTRIGLDGRPRPDLGTLHAIVAAHNRSIPFENLDPLLGIPVADLSAEA
LFAKLVDRRRGGYCYEHNGLLGYVLEELGFEVERLSGRVVWMRADDAPLP
AQTHNVLSVAVPGADGRYLVDVGFGGQTLTSPIRLEAGPVQQTRHEPYRL
TRHGDDHTLAAQVRGEWQPLYTFTTEPRPRIDLEVGSWYVSTHPGSHFVT
GLTVAVVTDDARYNLRGRNLAVHRSGATEHIRFDSAAQVLDAIVNRFGID
LGDLAGRDVQARVAEVLDT
3D structure
PDB1w6f Binding of the Anti-Tubercular Drug Isoniazid to the Arylamine N-Acetyltransferase Protein from Mycobacterium Smegmatis
ChainB
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E39 R65 C70 H110 D127
Catalytic site (residue number reindexed from 1) E33 R59 C64 H104 D121
Enzyme Commision number 2.3.1.5: arylamine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ISZ B F38 C70 Y71 T109 F130 F204 F32 C64 Y65 T103 F124 F198
Gene Ontology
Molecular Function
GO:0004060 arylamine N-acetyltransferase activity
GO:0016407 acetyltransferase activity
GO:0016746 acyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:1w6f, PDBe:1w6f, PDBj:1w6f
PDBsum1w6f
PubMed15722451
UniProtO86309|NAT_MYCSM Arylamine N-acetyltransferase (Gene Name=nat)

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