Structure of PDB 1w3c Chain B

Receptor sequence

>1w3cB (length=173) Species: 11104 (Hepatitis C virus (isolate 1)) [Search protein sequence]

ITAYSQQTRGLLGCIITSLTGRDKNQVDGEVQVLSTATQSFLATCVNGVC
WTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWPAPPGARSMTPCTCGSS
DLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHVVG
IFRAAVCTRGVAKAVDFIPVESM

3D structure

PDB

1w3c The Design and Enzyme-Bound Crystal Structure of Indoline Based Peptidomimetic Inhibitors of Hepatitis C Virus Ns3 Protease

Chain

Resolution

2.3 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	H57 D81 G137 S139
Catalytic site (residue number reindexed from 1)	H55 D79 G135 S137
Enzyme Commision number	2.7.7.48: RNA-directed RNA polymerase. 3.4.21.98: hepacivirin. 3.4.22.- 3.6.1.15: nucleoside-triphosphate phosphatase. 3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	B	T4 A5 Y6 S7 Q8 Q9 T10 R11 C16 S20 Q28 D30 E32 V33 Q34 V35 L36 S37 K62 T63 L64 A65 R109	T2 A3 Y4 S5 Q6 Q7 T8 R9 C14 S18 Q26 D28 E30 V31 Q32 V33 L34 S35 K60 T61 L62 A63 R107
BS02	DN1	B	I3 T4	I1 T2
BS03	DN2	B	H57 K136 G137 S139 R155 A156 A157	H55 K134 G135 S137 R153 A154 A155

Gene Ontology

	Molecular Function
GO:0008236	serine-type peptidase activity

	Biological Process
GO:0006508	proteolysis
GO:0019087	transformation of host cell by virus

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Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:1w3c, PDBe:1w3c, PDBj:1w3c
PDBsum	1w3c
PubMed	15588076
UniProt	P26662\|POLG_HCVJA Genome polyprotein

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