Structure of PDB 1w2c Chain B

Receptor sequence
>1w2cB (length=249) Species: 9606 (Homo sapiens) [Search protein sequence]
SFKAAGTSGLILKRCSEPERYCLARLMADALRGCVPAFHGVVERDGESYL
QLQDLLDGFDGPCVLDCKMGVRTYLEEELTKKLRKDMYKKMLAVDPAVTK
PRYMQWREGISSSTTLGFRIEGIKKADGSCSTDFKTTRSREQVLRVFEEF
VQGDEEVLRRYLNRLQQIRDTLEVSEFFRRHEVIGSSLLFVHDHCHRAGV
WLIDFGKTTPLPDGQILDHRRPWEEGNREDGYLLGLDNLIGILASLAER
3D structure
PDB1w2c Structure of a Human Inositol 1,4,5-Trisphosphate 3-Kinase; Substrate Binding Reveals Why It is not a Phosphoinositide 3-Kinase
ChainB
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.127: inositol-trisphosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP B F198 K209 L251 D262 L401 I415 D416 F2 K13 L55 D66 L189 I203 D204
BS02 I3P B K264 R285 K291 K312 Y315 M316 R319 K419 K68 R84 K90 K100 Y103 M104 R107 K207
Gene Ontology
Molecular Function
GO:0016301 kinase activity
Biological Process
GO:0032958 inositol phosphate biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1w2c, PDBe:1w2c, PDBj:1w2c
PDBsum1w2c
PubMed15350214
UniProtP23677|IP3KA_HUMAN Inositol-trisphosphate 3-kinase A (Gene Name=ITPKA)

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