Structure of PDB 1w1y Chain B

Receptor sequence
>1w1yB (length=497) Species: 615 (Serratia marcescens) [Search protein sequence]
TRKAVIGYYFIPTNQINNYTETDTSVVPFPVSNITPAKAKQLTHINFSFL
DINSNLECAWDPATNDAKARDVVNRLTALKAHNPSLRIMFSIGGWYYSND
LGVSHANYVNAVKTPASRAKFAQSCVRIMKDYGFDGVDIDWEYPQAAEVD
GFIAALQEIRTLLNQQTITDGRQALPYQLTIAGAGGAFFLSRYYSKLAQI
VAPLDYINLMTYDLAGPWEKVTNHQAALFGDAAGPTFYNALREANLGWSW
EELTRAFPSPFSLTVDAAVQQHLMMEGVPSAKIVMGVPFYGRAFKGVSGG
NGGQYSSHSTPGEDPYPSTDYWLVGCEECVRDKDPRIASYRQLEQMLQGN
YGYQRLWNDKTKTPYLYHAQNGLFVTYDDAESFKYKAKYIKQQQLGGVMF
WHLGQDNRNGDLLAALDRYFNAADYDDSQLDMGTGLRYTGVGPGNLPIMT
APAYVPGTTYAQGALVSYQGYVWQTKWGYITSAPGSDSAWLKVGRVA
3D structure
PDB1w1y Structure-Based Exploration of Cyclic Dipeptide Chitinase Inhibitors
ChainB
Resolution1.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D140 D142 E144 Y214
Catalytic site (residue number reindexed from 1) D138 D140 E142 Y212
Enzyme Commision number 3.2.1.14: chitinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TYP B Y10 F51 G96 W97 Y98 E144 Y214 R294 W403 Y8 F49 G94 W95 Y96 E142 Y212 R292 W401 MOAD: ic50=2.4mM
BS02 TYP B F12 F51 G96 Y98 D334 W403 F10 F49 G94 Y96 D332 W401 MOAD: ic50=2.4mM
BS03 TYP B W97 W220 W95 W218 MOAD: ic50=2.4mM
BS04 TYP B R162 N166 P178 A204 P205 L206 R160 N164 P176 A202 P203 L204 MOAD: ic50=2.4mM
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004568 chitinase activity
GO:0008061 chitin binding
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0030246 carbohydrate binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006032 chitin catabolic process
Cellular Component
GO:0005576 extracellular region

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Cellular Component
External links
PDB RCSB:1w1y, PDBe:1w1y, PDBj:1w1y
PDBsum1w1y
PubMed15509170
UniProtQ54276

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