Structure of PDB 1vcl Chain B

Receptor sequence

>1vclB (length=432) Species: 40245 (Cucumaria echinata) [Search protein sequence]

QVLCTNPLDIGELRSFKSKQCVDIVGNQGSGNIATYDCDGLSDQQIIICG
DGTIRNEARNYCFTPDGSGNANVMSSPCTLYPEIPSSQRWRQGRRKTFTD
NGGIEQVATEIINLASGKCLDIEGSDGTGDIGVYDCQNLDDQYFYVRSRG
PELFYGRLRNEKSDLCLDVEGSDGKGNVLMYSCEDNLDQWFRYYENGEIV
NAKSGMCLDVEGSDGSGNVGIYRCDDLRDQMWSRPNAYCNGDYCSFLNKE
SNKCLDVSGDQGTGDVGTWQCDGLPDQRFKWVFDDWEVPTATWNMVGCDQ
NGKVSQQISNTISFSSTVTAGVAVEVSSTIEKGVIFAKATVSVKVTASLS
KAWTNSQSGTTAITYTCDNYDSDEEFTRGCMWQLAIETTEVKSGDLLVWN
PQIVKCTRSNTAPGCAPFTKCANEDCTFCTDI

3D structure

PDB

1vcl Crystal Structure of the Hemolytic Lectin CEL-III Isolated from the Marine Invertebrate Cucumaria echinata: IMPLICATIONS OF DOMAIN STRUCTURE FOR ITS MEMBRANE PORE-FORMATION MECHANISM

Chain

Resolution

1.7 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CA	B	D23 I24 G26 D43	D23 I24 G26 D43
BS02	CA	B	D121 I122 G124 D141	D121 I122 G124 D141
BS03	CA	B	D168 V169 G171 D188	D168 V169 G171 D188
BS04	CA	B	D209 V210 G212 D229	D209 V210 G212 D229
BS05	CA	B	D256 V257 G259 D276	D256 V257 G259 D276
BS06	MG	B	N32 I33 N72 V73 I131	N32 I33 N72 V73 I131
BS07	MG	B	N177 V178 N218 V219 D265 V266	N177 V178 N218 V219 D265 V266

Gene Ontology

	Molecular Function
GO:0000287	magnesium ion binding
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity
GO:0005509	calcium ion binding
GO:0005534	galactose binding
GO:0030246	carbohydrate binding
GO:0030395	lactose binding
GO:0042806	fucose binding
GO:0046871	N-acetylgalactosamine binding
GO:0046872	metal ion binding
GO:1903777	melibiose binding

	Biological Process
GO:0001906	cell killing
GO:0006493	protein O-linked glycosylation
GO:0019731	antibacterial humoral response
GO:0031640	killing of cells of another organism
GO:0034120	positive regulation of erythrocyte aggregation
GO:0042742	defense response to bacterium
GO:0044179	hemolysis in another organism
GO:0050829	defense response to Gram-negative bacterium
GO:0050830	defense response to Gram-positive bacterium
GO:0051260	protein homooligomerization
GO:0051673	disruption of plasma membrane integrity in another organism

	Cellular Component
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005794	Golgi apparatus

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:1vcl, PDBe:1vcl, PDBj:1vcl
PDBsum	1vcl
PubMed	15194688
UniProt	Q868M7\|CEL3_CUCEC Galactose/N-acetylgalactosamine-binding lectin CEL-III (Gene Name=cel3)

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