Structure of PDB 1vc9 Chain B

Receptor sequence
>1vc9B (length=126) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
MELGAGGVVFNAKREVLLLRDRMGFWVFPKGHPEPGESLEEAAVREVWEQ
TGVRAEVLLPLYPTRYVNPKGVEREVHWFLMRGEGAPRLEEGMTGAGWFS
PEEARALLAFPEDLGLLEVALERLPL
3D structure
PDB1vc9 Crystal Structure of Nudix Protein Ndx1 from Thermus thermophilus HB8 in binary complex with diadenosine hexaphosphate
ChainB
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.61: diadenosine hexaphosphate hydrolase (ATP-forming).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP B D21 M23 F25 K30 H32 Y66 N68 P69 R74 F110 E112 D21 M23 F25 K30 H32 Y66 N68 P69 R74 F110 E112 MOAD: Kd=13uM
Gene Ontology
Molecular Function
GO:0004081 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0046872 metal ion binding
Biological Process
GO:0006167 AMP biosynthetic process
GO:0006754 ATP biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1vc9, PDBe:1vc9, PDBj:1vc9
PDBsum1vc9
PubMed
UniProtQ75UV1|NDX1_THETH Diadenosine hexaphosphate hydrolase (Gene Name=ndx1)

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