Structure of PDB 1vbj Chain B

Receptor sequence
>1vbjB (length=279) Species: 5691 (Trypanosoma brucei) [Search protein sequence]
PEFMALTQSLKLSNGVMMPVLGFGMWKLQDGNEAETATMWAIKSGYRHID
TAAIYKNEESAGRAIASCGVPREELFVTTKLWNSDQGYESTLSAFEKSIK
KLGLEYVDLYLIHWPGKDKFIDTWKAFEKLYADKKVRAIGVSNFHEHHIE
ELLKHCKVAPMVNQIELHPLLNQKALCEYCKSKNIAVTAWSPLGQGHLVE
DARLKAIGGKYGKTAAQVMLRWEIQAGVITIPKSGNEARIKENGNIFDFE
LTAEDIQVIDGMNAGHRYGPDPEVFMNDF
3D structure
PDB1vbj The crystal structure of prostaglandin F synthase from Trypanosoma brucei
ChainB
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D47 Y52 K77 H110
Catalytic site (residue number reindexed from 1) D50 Y55 K80 H113
Enzyme Commision number 1.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP B G21 M22 W23 D47 Y52 K77 H110 Q161 W187 S188 P189 L190 Q192 G193 V196 A213 I228 P229 K230 S231 G232 R236 E239 N240 G24 M25 W26 D50 Y55 K80 H113 Q164 W190 S191 P192 L193 Q195 G196 V199 A216 I231 P232 K233 S234 G235 R239 E242 N243
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004033 aldo-keto reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0036130 prostaglandin H2 endoperoxidase reductase activity
GO:0045290 D-arabinose 1-dehydrogenase [NAD(P)+] activity
Biological Process
GO:0001516 prostaglandin biosynthetic process
GO:0019571 D-arabinose catabolic process
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1vbj, PDBe:1vbj, PDBj:1vbj
PDBsum1vbj
PubMed
UniProtQ9GV41|PGFS_TRYBB 9,11-endoperoxide prostaglandin H2 reductase

[Back to BioLiP]