Structure of PDB 1uzr Chain B

Receptor sequence
>1uzrB (length=288) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
DRVSAINWNRLQDEKDAEVWDRLTGNFWLPEKVPVSNDIPSWGTLTAGEK
QLTMRVFTGLTMLDTIQGTVGAVSLIPDALTPHEEAVLTNIAFMESVHAK
SYSQIFSTLCSTAEIDDAFRWSEENRNLQRKAEIVLQSYRGDEPLKRKVA
STLLESFLFYSGFYLPMYWSSRAKLTNTADMIRLIIRDEAVHGYYIGYKF
QRGLALVDDVTRAELKDYTYELLFELYDNEVEYTQDLYDEVGLTEDVKKF
LRYNANKALMNLGYEALFPRDETDVNPAILSALSPNAD
3D structure
PDB1uzr Crystal Structure of the Biologically Active Form of Class Ib Ribonucleotide Reductase Small Subunit from Mycobacterium Tuberculosis
ChainB
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y110 D196
Catalytic site (residue number reindexed from 1) Y102 D188
Enzyme Commision number 1.17.4.1: ribonucleoside-diphosphate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE B D72 E103 H106 E197 D64 E95 H98 E189
BS02 FE B E103 E163 E197 H200 E95 E155 E189 H192
Gene Ontology
Molecular Function
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0009263 deoxyribonucleotide biosynthetic process
Cellular Component
GO:0005971 ribonucleoside-diphosphate reductase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1uzr, PDBe:1uzr, PDBj:1uzr
PDBsum1uzr
PubMed15225619
UniProtP9WH71|RIR2B_MYCTU Ribonucleoside-diphosphate reductase subunit beta nrdF2 (Gene Name=nrdF2)

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