Structure of PDB 1usx Chain B

Receptor sequence
>1usxB (length=446) [Search protein sequence]
GAPIHDPDFIGGIGKELIVDNASDVTSFYPSAFQEHLNFIPAPTTGSGCT
RIPSFDMSATHYCYTHNVILSGCRDHSHSHQYLALGVLRTTATGRIFFST
LRSISLDDTQNRKSCSVSATPLGCDMLCSKVTETEEEDYNSAVPTLMAHG
RLGFDGQYHEKDLDVTTLFEDWVANYPGVGGGSFIDGRVWFSVYGGLKPN
SPSDTVQEGKYVIYKRYNDTCPDEQDYQIRMAKSSYKPGRFGGKRIQQAI
LSIKVSTSLGEDPVLTVPPNTVTLMGAEGRILTVGTSHFLYQRGSSYFSP
ALLYPMTVSNKTATLHSPYTFNAFTRPGSIPCQASARCPNSCVTGVYTDP
YPLIFYRNHTLRGVFGTMLDSEQARLNPASAVFDSTSRSRITRVSSSSTK
AAYTTSTCFKVVKTNKTYCLSIAEISNTLFGEFRIVPLLVEILKND
3D structure
PDB1usx Second Sialic Acid Binding Site in Newcastle Disease Virus Hemagglutinin-Neuraminidase: Implications for Fusion
ChainB
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SIA B T168 G169 T45 G46
BS02 SIA B F156 T515 R516 S518 S519 F33 T392 R393 S395 S396
BS03 DAN B R174 E258 Y317 E401 R416 R498 Y526 R51 E135 Y194 E278 R293 R375 Y403
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
GO:0046789 host cell surface receptor binding
Biological Process
GO:0019058 viral life cycle
Cellular Component
GO:0019031 viral envelope

View graph for
Molecular Function
View graph for
Biological Process
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Cellular Component
External links
PDB RCSB:1usx, PDBe:1usx, PDBj:1usx
PDBsum1usx
PubMed15016893
UniProtP32884|HN_NDVB Hemagglutinin-neuraminidase (Gene Name=HN)

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