Structure of PDB 1uej Chain B

Receptor sequence
>1uejB (length=207) Species: 9606 (Homo sapiens) [Search protein sequence]
GEPFLIGVSGGTASGKSSVCAKIVQLLGQQKQVVILSQDSFYRVLTSEQK
AKALKGQFNFDHPDAFDNELILKTLKEITEGKTVQIPVYDFVSHSRKEET
VTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISE
RGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIPRGADNLVAINLIVQ
HIQDILN
3D structure
PDB1uej Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase
ChainB
Resolution2.61 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.48: uridine/cytidine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CTN B D62 Y65 F83 D84 Y112 F114 H117 R166 R174 R176 D39 Y42 F60 D61 Y89 F91 H94 R143 R151 R153
Gene Ontology
Molecular Function
GO:0004849 uridine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0042802 identical protein binding
GO:0043771 cytidine kinase activity
Biological Process
GO:0009224 CMP biosynthetic process
GO:0016310 phosphorylation
GO:0044206 UMP salvage
GO:0044211 CTP salvage
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1uej, PDBe:1uej, PDBj:1uej
PDBsum1uej
PubMed15130468
UniProtQ9BZX2|UCK2_HUMAN Uridine-cytidine kinase 2 (Gene Name=UCK2)

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