Structure of PDB 1udw Chain B

Receptor sequence
>1udwB (length=209) Species: 9606 (Homo sapiens) [Search protein sequence]
EPFLIGVSGGTASGKSSVCAKIVQLLGQYRQKQVVILSQDSFYRVLTSEQ
KAKALKGQFNFDHPDAFDNELILKTLKEITEGKTVQIPVYDFVSHSRKEE
TVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDIS
ERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIPRGADNLVAINLIV
QHIQDILNG
3D structure
PDB1udw Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase
ChainB
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.48: uridine/cytidine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CTP B T29 A30 S31 G32 K33 S34 Y65 F83 D84 Y112 F114 E135 R166 R169 R174 R176 Q184 T11 A12 S13 G14 K15 S16 Y43 F61 D62 Y90 F92 E113 R144 R147 R152 R154 Q162
Gene Ontology
Molecular Function
GO:0004849 uridine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0042802 identical protein binding
GO:0043771 cytidine kinase activity
Biological Process
GO:0009224 CMP biosynthetic process
GO:0016310 phosphorylation
GO:0044206 UMP salvage
GO:0044211 CTP salvage
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1udw, PDBe:1udw, PDBj:1udw
PDBsum1udw
PubMed15130468
UniProtQ9BZX2|UCK2_HUMAN Uridine-cytidine kinase 2 (Gene Name=UCK2)

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