Structure of PDB 1udu Chain B

Receptor sequence
>1uduB (length=313) Species: 9606 (Homo sapiens) [Search protein sequence]
TRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQ
NFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQN
KLTDLEILALLIAALSHDLDHRGVNNSYYCHSIMEHHHFDQCLMILNSPG
NQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLE
DPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKEL
NIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCR
KNRQKWQALAEQQ
3D structure
PDB1udu Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules
ChainB
Resolution2.83 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.35: 3',5'-cyclic-GMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H617 H653 D654 D764 H81 H117 D118 D217
BS02 MG B D654 T723 D118 T176
BS03 CIA B Y612 Q775 I778 V782 A783 F786 L804 M816 Q817 F820 Y76 Q228 I231 V235 A236 F239 L257 M269 Q270 F273 BindingDB: IC50=4nM,Ki=10nM
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:1udu, PDBe:1udu, PDBj:1udu
PDBsum1udu
PubMed12955149
UniProtO76074|PDE5A_HUMAN cGMP-specific 3',5'-cyclic phosphodiesterase (Gene Name=PDE5A)

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