Structure of PDB 1u3s Chain B

Receptor sequence
>1u3sB (length=223) Species: 9606 (Homo sapiens) [Search protein sequence]
LSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISW
AKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVL
DRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSSSR
KLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGME
HLLNMKCKNVVPVYDLLLEMLNA
3D structure
PDB1u3s Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands.
ChainB
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I310 K314 L324 E493 I48 K52 L62 E219
BS02 797 B M295 E305 L339 M340 L343 F356 I376 H475 L476 M33 E43 L77 M78 L81 F94 I114 H201 L202 MOAD: ic50=1.4nM
BindingDB: IC50=1.4nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:1u3s, PDBe:1u3s, PDBj:1u3s
PDBsum1u3s
PubMed15456246
UniProtQ92731|ESR2_HUMAN Estrogen receptor beta (Gene Name=ESR2)

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