Structure of PDB 1u3r Chain B

Receptor sequence
>1u3rB (length=227) Species: 9606 (Homo sapiens) [Search protein sequence]
LSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISW
AKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVL
DRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSSSR
KLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGME
HLLNMKCKNVVPVYDLLLEMLNAHVLR
3D structure
PDB1u3r Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands.
ChainB
Resolution2.21 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I310 K314 V328 E493 I48 K52 V66 E219
BS02 338 B L298 E305 L339 F356 H475 L476 L36 E43 L77 F94 H201 L202 MOAD: ic50=5nM
BindingDB: IC50=5nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:1u3r, PDBe:1u3r, PDBj:1u3r
PDBsum1u3r
PubMed15456246
UniProtQ92731|ESR2_HUMAN Estrogen receptor beta (Gene Name=ESR2)

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