Structure of PDB 1tzd Chain B

Receptor sequence
>1tzdB (length=242) Species: 10116 (Rattus norvegicus) [Search protein sequence]
GLILKRSSEPEHYCMVRLMADVLRGCVPAFHGVVLQLQDLLDGFDGPCVL
DCKMGVRTYLEEELTKARERPKLRKDMYKKMLAVDPEAPTEEEHAPRYMQ
WREGISSSTTLGFRIEGIKKADGSCSTDFKTTRSREQVTRVFEEFMQGDA
EVLKRYLNRLQQIRDTLEISDFFRRHEVIGSSLLFVHDHCHRAGVWLIDF
GKTTPLPNGQILDHRRPWEEGNREDGYLLGLDNLIGILANLA
3D structure
PDB1tzd Crystal structure of the catalytic core of inositol 1,4,5-trisphosphate 3-kinase
ChainB
Resolution2.2 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.1.127: inositol-trisphosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B K207 L249 D260 L399 I413 D414 K5 L40 D51 L184 I198 D199
Gene Ontology
Molecular Function
GO:0016301 kinase activity
Biological Process
GO:0032958 inositol phosphate biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1tzd, PDBe:1tzd, PDBj:1tzd
PDBsum1tzd
PubMed15350215
UniProtP17105|IP3KA_RAT Inositol-trisphosphate 3-kinase A (Gene Name=Itpka)

[Back to BioLiP]