Structure of PDB 1tzc Chain B

Receptor sequence

>1tzcB (length=301) Species: 178306 (Pyrobaculum aerophilum str. IM2)

SQLLQDYLNWENYILRRVDFPTSYVVEGEVVRIEAMPRLYISGMGGSGVV
ADLIRDFSLTWNWEVEVIAVKDYFLKARDGLLIAVSYSGNTIETLYTVEY
AKRRRIPAVAITTGGRLAQMGVPTVIVPKASAPRAALPQLLTAALHVVAK
VYGIDVKIPEGLEPPNEALIHKLVEEFQKRPTIIAAESMRGVAYRVKNEF
NENAKIEPSVEILPEAHHNWIEGSERAVVALTSPHIPKEHQERVKATVEI
VGGSIYAVEMHPKGVLSFLRDVGIASVKLAEIRGVNPLATPRIDALKRRL
Q

3D structure

• PDB: 1tzc A novel phosphoglucose/phosphomannose isomease from the crenarchaeon Pyrobaculum aerophilum is a member of the PGI superfamily: structural evidence at 1.16 A resolution
• Chain: B
• Resolution: 1.45 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): R135 E203 H219 K298
• Catalytic site (residue number reindexed from 1): R134 E202 H218 K297
• Enzyme Commision number: 5.3.1.8: mannose-6-phosphate isomerase.
  5.3.1.9: glucose-6-phosphate isomerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	PA5	B	G47 S48 S87 Y88 S89 T92 P134 R135 E203 K298	G46 S47 S86 Y87 S88 T91 P133 R134 E202 K297

Gene Ontology

Molecular Function

• GO:0004347 glucose-6-phosphate isomerase activity
• GO:0004476 mannose-6-phosphate isomerase activity
• GO:0016853 isomerase activity
• GO:0097367 carbohydrate derivative binding

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:1901135 carbohydrate derivative metabolic process

External links

• PDB: RCSB:1tzc, PDBe:1tzc, PDBj:1tzc
• PDBsum: 1tzc
• PubMed: 15252053
• UniProt: Q8ZWV0|PGMI_PYRAE Bifunctional phosphoglucose/phosphomannose isomerase (Gene Name=PAE1610)