Structure of PDB 1tq2 Chain B

Receptor sequence
>1tq2B (length=392) Species: 10090 (Mus musculus) [Search protein sequence]
NDLPSSFTGYFKKFNTGRKIISQEILNLIELRMRKGNIQLTNSAISDALK
EIDSSVLNVAVTGETGSGKSSFINTLRGIGNEEEGAAKTGVVEVTMERHP
YKHPNIPNVVFWDLPGIGSTNFPPDTYLEKMKFYEYDFFIIISATRFKKN
DIDIAKAISMMKKEFYFVRTKVDSDITNEEKVLQDIRLNCVNTFRENGIA
EPPIFLLSNKNVCHYDFPVLMDKLISDLPIYKRHNFMVSLPNITDSVIEK
KRQFLKQRIWLEGFAADLVNIIPSLTFLLDSDLETLKKSMKFYRTVFGVD
ETSLQRLARDWEIEVDQVEAMIKSPAVFKPTDEETIQERLSRYIQEFCLA
NGYLLPKNSFLKEIFYLKYYFLDMVTEDAKTLLKEICLKLGR
3D structure
PDB1tq2 Crystal Structure of IIGP1; A Paradigm for Interferon-Inducible p47 Resistance GTPases
ChainB
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP B T78 G79 G81 K82 S83 S84 G103 K184 D186 S187 S231 N232 K233 T65 G66 G68 K69 S70 S71 G90 K171 D173 S174 S208 N209 K210
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0019003 GDP binding
GO:0042802 identical protein binding
Biological Process
GO:0009617 response to bacterium
GO:0010506 regulation of autophagy
GO:0019221 cytokine-mediated signaling pathway
GO:0035458 cellular response to interferon-beta
GO:0042832 defense response to protozoan
GO:0045087 innate immune response
GO:0050829 defense response to Gram-negative bacterium
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0020005 symbiont-containing vacuole membrane
GO:0031965 nuclear membrane
GO:0032580 Golgi cisterna membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1tq2, PDBe:1tq2, PDBj:1tq2
PDBsum1tq2
PubMed15350217
UniProtQ9QZ85|IIGP1_MOUSE Interferon-inducible GTPase 1 (Gene Name=Iigp1)

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