Structure of PDB 1tco Chain B

Receptor sequence
>1tcoB (length=169) Species: 9913 (Bos taurus) [Search protein sequence]
GNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQ
NPLVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFAFRIYDM
DKDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTIINADKDGDGRISFE
EFCAVVGGLDIHKKMVVDV
3D structure
PDB1tco X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex.
ChainB
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B D30 D32 S34 S36 L37 E41 D30 D32 S34 S36 L37 E41
BS02 CA B D62 D64 N66 E68 E73 D62 D64 N66 E68 E73
BS03 CA B D99 D101 D103 Y105 E110 D99 D101 D103 Y105 E110
BS04 CA B D140 D142 D144 R146 E151 D140 D142 D144 R146 E151
BS05 FK5 B M118 V119 M118 V119
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity
GO:0019902 phosphatase binding
GO:0046872 metal ion binding
Biological Process
GO:0097720 calcineurin-mediated signaling
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005955 calcineurin complex
GO:0042383 sarcolemma

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Molecular Function
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Cellular Component
External links
PDB RCSB:1tco, PDBe:1tco, PDBj:1tco
PDBsum1tco
PubMed7543369
UniProtP63099|CANB1_BOVIN Calcineurin subunit B type 1 (Gene Name=PPP3R1)

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