Structure of PDB 1t7d Chain B

Receptor sequence
>1t7dB (length=223) Species: 562 (Escherichia coli) [Search protein sequence]
IYEPFQIPSGSMMPTLLIGDFILVEKFAETGHPKRGDIVVFKYPEDPKLD
YIKRAVGLPGDKVTYDPVSKELTIQPGCSSGQACENALPVTYSNVEPSDF
VQTFSSGFFEVPKNETKENGIRLSERKETLGDVTHRILTVPIAQDQVGMY
YQQPGQQLATWIVPPGQYFMMGDNRDNSADSRYWGFVPEANLVGRATAIW
MSFDKQEGEWPTGLRLSRIGGIH
3D structure
PDB1t7d Crystallographic and Biophysical Analysis of a Bacterial Signal Peptidase in Complex with a Lipopeptide Based Inhibitor.
ChainB
Resolution2.47 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S88 S90 K145 S278
Catalytic site (residue number reindexed from 1) S9 S11 K53 S178
Enzyme Commision number 3.4.21.89: signal peptidase I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B P83 Q85 P87 D142 Y143 I144 K145 P4 Q6 P8 D50 Y51 I52 K53
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006465 signal peptide processing
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:1t7d, PDBe:1t7d, PDBj:1t7d
PDBsum1t7d
PubMed15136583
UniProtP00803|LEP_ECOLI Signal peptidase I (Gene Name=lepB)

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