Structure of PDB 1t39 Chain B

Receptor sequence
>1t39B (length=148) Species: 9606 (Homo sapiens) [Search protein sequence]
MKRTTLDSPLGKLELSGCEQGLHEIKLLGPEPLMQCTAWLNAYFHQPEAI
EEFPVPALHHPVFQQESFTRQVLWKLLKVVKFGEVISYQQLAALAGNPKA
ARAVGGAMRGNPVPILIPCHRVVCSSGAVGNYSGGLAVKEWLLAHEGH
3D structure
PDB1t39 DNA binding and nucleotide flipping by the human DNA repair protein AGT.
ChainB
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.63: methylated-DNA--[protein]-cysteine S-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B Y114 Q115 R128 R135 C145 V148 C150 S151 N157 Y158 S159 Y88 Q89 R102 R109 C119 V122 C124 S125 N131 Y132 S133
BS02 dna B S93 F94 T95 R128 A129 S67 F68 T69 R102 A103
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003908 methylated-DNA-[protein]-cysteine S-methyltransferase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:1t39, PDBe:1t39, PDBj:1t39
PDBsum1t39
PubMed15221026
UniProtP16455|MGMT_HUMAN Methylated-DNA--protein-cysteine methyltransferase (Gene Name=MGMT)

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