Structure of PDB 1t0a Chain B

Receptor sequence
>1t0aB (length=158) Species: 211586 (Shewanella oneidensis MR-1) [Search protein sequence]
KIRIGHGFDVHKFGEPRPLILCGVEVPYETGLVAHSDGDVVLHAISDAIL
GAMALGDIGKHFPDTDAAYKGADSRVLLRHCYALAKAKGFELGNLDVTII
AQAPKMAPHIEDMRQVLAADLNADVADINVKATTTEKLGFTGRKEGIAVE
AVVLLSRQ
3D structure
PDB1t0a Structure of 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase from Shewanella oneidensis at 1.6 A: identification of farnesyl pyrophosphate trapped in a hydrophobic cavity.
ChainB
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.6.1.12: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FPP B F9 G140 F141 R144 F8 G139 F140 R143
BS02 ZN B D10 H12 H44 D9 H11 H43
Gene Ontology
Molecular Function
GO:0008685 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0016114 terpenoid biosynthetic process
GO:0019288 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:1t0a, PDBe:1t0a, PDBj:1t0a
PDBsum1t0a
PubMed15502301
UniProtQ8EBR3|ISPF_SHEON 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (Gene Name=ispF)

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