Structure of PDB 1szf Chain B

Receptor sequence
>1szfB (length=389) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
GETKEDIARKEQLKSLLPPLDNIINLYDFEYLASQTLTKQAWAYYSSGAN
DEVTHRENHNAYHRIFFKPKILVDVRKVDISTDMLGSHVDVPFYVSATGL
CKLGNPLEGEKDVARGCGQGVTKVPQMISTAASCSPEEIIEAAPSDKQIQ
WYQLYVNSDRKITDDLVKNVEKLGVKALFVTVDAPSLGQREKDMKLKFAL
SKFIDPSLTWKDIEELKKKTKLPIVIKGVQRTEDVIKAAEIGVSGVVLSN
HGGRQLDFSRAPIEVLAETMPILEQRNLKDKLEVFVDGGVRRGTDVLKAL
CLGAKGVGLGRPFLYANSCYGRNGVEKAIEILRDEIEMSMRLLGVTSIAE
LKPDLLDLSTLKARTVGVPNDVLYNEVYEGPTLTEFEDA
3D structure
PDB1szf Altered Substrate Specificity in Flavocytochrome b(2): Structural Insights into the Mechanism of l-Lactate Dehydrogenation
ChainB
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S228 Y254 T280 D282 K349 H373
Catalytic site (residue number reindexed from 1) S129 Y155 T181 D183 K227 H251
Enzyme Commision number 1.1.2.3: L-lactate dehydrogenase (cytochrome).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMN B Y143 Y144 S195 A196 T197 G198 S228 Q252 Y254 T280 K349 H373 G374 R376 D409 G410 G411 R413 G432 R433 Y44 Y45 S96 A97 T98 G99 S129 Q153 Y155 T181 K227 H251 G252 R254 D287 G288 G289 R291 G310 R311
BS02 PYR B Y143 H373 R376 Y44 H251 R254
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0020037 heme binding

View graph for
Molecular Function
External links
PDB RCSB:1szf, PDBe:1szf, PDBj:1szf
PDBsum1szf
PubMed15260495
UniProtP00175|CYB2_YEAST L-lactate dehydrogenase (cytochrome) (Gene Name=CYB2)

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