Structure of PDB 1syo Chain B

Receptor sequence
>1syoB (length=408) Species: 9913 (Bos taurus) [Search protein sequence]
AEFPELCSYTWEAVDTKNNMLYKINICGNMGVAQCGPSSAVCMHDLKTDS
FHSVGDSLLKTASRSLLEFNTTVNIQSSITFLCGKTLGTPEFVTATDCVH
YFEWRTTAACKKNIFKANKEVPCYAFDRELKKHDLNPLIKTSGAYLVDDS
DPDTSLFINVCRDIEVLRASSPQVRVCPTGAAACLVRGDRAFDVGRPQEG
LKLVSNDRLVLSYVKFCDGHSPAVTITFVCPSERREGTIPKLTAKSNCRF
EIEWVTEYACHRDYLESRSCSLSSAQHDVAVDLQPLSRVSLFYTSEADEY
TYYLSICGGSQAPICNKKDAAVCQVKKADSTQVKVAGRPQNLTLRYSDGD
LTLIYFGGEECSSGFQRMSVINFECNQTAGNNGRGAPVFTGEVDCTYFFT
WDTKYACV
3D structure
PDB1syo The N-terminal carbohydrate recognition site of the cation-independent mannose 6-phosphate receptor
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 M6P B Y1324 Q1348 C1385 S1386 R1391 E1416 C1419 Y1421 Y300 Q324 C361 S362 R367 E392 C395 Y397 MOAD: Kd~1nM
PDBbind-CN: -logKd/Ki=9.00,Kd~1nM
Gene Ontology
Molecular Function
GO:0005537 D-mannose binding
GO:0038023 signaling receptor activity
Biological Process
GO:0007041 lysosomal transport

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Molecular Function
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Biological Process
External links
PDB RCSB:1syo, PDBe:1syo, PDBj:1syo
PDBsum1syo
PubMed15169779
UniProtP08169|MPRI_BOVIN Cation-independent mannose-6-phosphate receptor (Gene Name=IGF2R)

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