Structure of PDB 1syi Chain B

Receptor sequence
>1syiB (length=259) Species: 10116 (Rattus norvegicus) [Search protein sequence]
NKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYK
LTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDF
SKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKI
AVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAFLLESTMNEYIEQ
RKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKN
KWWYDKGEC
3D structure
PDB1syi Tyr702 Is an Important Determinant of Agonist Binding and Domain Closure of the Ligand-Binding Core of GluR2.
ChainB
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CPW B Y58 L87 T88 R93 L135 G138 S139 T140 L189 E190 Y59 L88 T89 R94 L136 G139 S140 T141 L190 E191 MOAD: Ki=3330nM
BindingDB: Ki=223nM,EC50=13900nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:1syi, PDBe:1syi, PDBj:1syi
PDBsum1syi
PubMed15591246
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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