Structure of PDB 1su3 Chain B

Receptor sequence
>1su3B (length=416) Species: 9606 (Homo sapiens) [Search protein sequence]
VDLVQKYLEKYYNLKSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPR
CGVPDVAPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTF
TKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDE
DERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLA
QDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKD
RFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYW
AVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWR
YDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDP
KTKRILTLQKANSWFN
3D structure
PDB1su3 X-ray structure of human proMMP-1: new insights into procollagenase activation and collagen binding.
ChainB
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H218 E219 H222 H228
Catalytic site (residue number reindexed from 1) H169 E170 H173 H179
Enzyme Commision number 3.4.24.7: interstitial collagenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B D158 G190 G192 D194 D109 G141 G143 D145
BS02 CA B D175 G176 G178 N180 D198 E201 D126 G127 G129 N131 D149 E152
BS03 CA B D124 E199 E201 D75 E150 E152
BS04 CA B D285 E329 D378 D427 D236 E280 D329 D378
BS05 ZN B C92 H218 H222 H228 C51 H169 H173 H179
BS06 ZN B H168 D170 H183 H196 H119 D121 H134 H147
Gene Ontology
Molecular Function
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030574 collagen catabolic process
GO:0031334 positive regulation of protein-containing complex assembly
GO:0071492 cellular response to UV-A
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0031012 extracellular matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1su3, PDBe:1su3, PDBj:1su3
PDBsum1su3
PubMed15611040
UniProtP03956|MMP1_HUMAN Interstitial collagenase (Gene Name=MMP1)

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