Structure of PDB 1st0 Chain B

Receptor sequence
>1st0B (length=297) Species: 9606 (Homo sapiens) [Search protein sequence]
VRLPFSGFRLQKVLRESARDKIIFLHGKVNEASGDGDGEDAVVILEKTPF
QVEQVAQLLTGSPELQLQFSNDIYSTYHLFPPRQLNDVKTTVVYPATEKH
LQKYLRQDLRLIRETGDDYRNITLPHLESQSLSIQWVYNILDKKAEADRI
VFENPDPSDGFVLIPDLKWNQQQLDDLYLIAICHRRGIRSLRDLTPEHLP
LLRNILHQGQEAILQRYRMKGDHLRVYLHYLPSYYHLNVHFTALGFEAPG
SGVERAHLLAEVIENLECDPRHYQQRTLTFALRADDPLLKLLQEAQQ
3D structure
PDB1st0 Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity
ChainB
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.59: 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTG B R145 W175 E185 D205 L206 K207 I219 H268 S272 Y273 N277 H279 R294 R322 R106 W136 E146 D166 L167 K168 I180 H229 S233 Y234 N238 H240 R255 R283
BS02 GTG B F108 Y113 F69 Y74
Gene Ontology
Molecular Function
GO:0000340 RNA 7-methylguanosine cap binding
GO:0004532 RNA exonuclease activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0042802 identical protein binding
GO:0140932 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0045292 mRNA cis splicing, via spliceosome
GO:0110156 mRNA methylguanosine-cap decapping
Cellular Component
GO:0000932 P-body
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1st0, PDBe:1st0, PDBj:1st0
PDBsum1st0
PubMed15068804
UniProtQ96C86|DCPS_HUMAN m7GpppX diphosphatase (Gene Name=DCPS)

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