Structure of PDB 1sqn Chain B

Receptor sequence
>1sqnB (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
LIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKW
SKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDL
ILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPL
EGLRSQTQFEEMRSSYIRELIKAIGLRQGVVSSSQRFYQLTKLLDNLHDL
VKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK
3D structure
PDB1sqn Progesterone receptor ligand binding pocket flexibility: crystal structures of the norethindrone and mometasone furoate complexes
ChainB
Resolution1.451 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDR B L721 Q725 M756 M759 Y890 C891 L39 Q43 M74 M77 Y207 C208 MOAD: Kd=0.4nM
BindingDB: Kd=0.4nM,Ki=1.9nM,IC50=3.2nM,EC50=2.2nM
External links
PDB RCSB:1sqn, PDBe:1sqn, PDBj:1sqn
PDBsum1sqn
PubMed15189034
UniProtP06401|PRGR_HUMAN Progesterone receptor (Gene Name=PGR)

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