Structure of PDB 1sq5 Chain B

Receptor sequence
>1sq5B (length=302) Species: 562 (Escherichia coli) [Search protein sequence]
MTPYLQFDRNQWAALRLSEDEIARLKGINEDLSLEEVAEIYLPLSRLLNF
YISSNLRRQAVLEQFLGTNGQRIPYIISIAGSVAVGKSTTARVLQALLSR
WPEHRRVELITTDGFLHPNQVLKERGLMKKKGFPESYDMHRLVKFVSDLK
SGVPNVTAPVYSHLIYDVIPDGDKTVVQPDILILEGLNVLQSGMDYPHDP
HHVFVSDFVDFSIYVDAPEDLLQTWYINRFLKFREGAFTDPDSYFHNYAK
LTKEEAIKTAMTLWKEINWLNLKQNILPTRERASLILTKSANHAVEEVRL
RK
3D structure
PDB1sq5 The structure of the pantothenate kinase.ADP.pantothenate ternary complex reveals the relationship between the binding sites for substrate, allosteric regulator, and antimetabolites.
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.33: pantothenate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PAU B D2127 K2145 G2146 Y2240 N2282 D113 K131 G132 Y226 N268
BS02 ADP B N2043 D2045 A2098 G2100 K2101 S2102 T2103 R2243 K2303 H2307 N29 D31 A84 G86 K87 S88 T89 R229 K289 H293
Gene Ontology
Molecular Function
GO:0004594 pantothenate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0042803 protein homodimerization activity
GO:0050165 pantetheine kinase activity
Biological Process
GO:0015937 coenzyme A biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:1sq5, PDBe:1sq5, PDBj:1sq5
PDBsum1sq5
PubMed15136582
UniProtP0A6I3|COAA_ECOLI Pantothenate kinase (Gene Name=coaA)

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