Structure of PDB 1sow Chain B

Receptor sequence
>1sowB (length=323) Species: 5811 (Toxoplasma gondii) [Search protein sequence]
GTVSRRKKIAMIGSGMIGGTMGYLCVLRELADVVLFDVVTGMPEGKALDD
SQATSIADTNVSVTSANQYEKIAGSDVVIITAGLTKVPGKSDKEWSRNDL
LPFNAKIIREVAQGVKKYCPLAFVIVVTNPLDCMVKCFHEASGLPKNMVC
GMANVLDSARFRRFIADQLEISPRDIQATVIGTHGDHMLPLARYVTVNGF
PLREFIKKGKMTEAKLAEIVERTKKAGGEIVRLLGQGSAYYAPALSAITM
AQAFLKDEKRVLPCSVYCQGEYGLHDMFIGLPAVIGGGGIEQVIELELTH
EEQECFRKSVDDVVELNKSLAAL
3D structure
PDB1sow Structure of apo and ternary forms of Toxoplasma gondii LDH2
ChainB
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R109 D168 R171 H195
Catalytic site (residue number reindexed from 1) R97 D157 R160 H184
Enzyme Commision number 1.1.1.27: L-lactate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OXL B W107 R109 R171 H195 G236 W95 R97 R160 H184 G227
BS02 NAD B G29 M30 I31 D53 V54 T97 A98 G99 L100 T101 I119 E122 V138 N140 M163 L167 H195 G15 M16 I17 D37 V38 T81 A82 G83 L84 T85 I107 E110 V127 N129 M152 L156 H184
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004459 L-lactate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process
GO:0006089 lactate metabolic process
GO:0006090 pyruvate metabolic process
GO:0019752 carboxylic acid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1sow, PDBe:1sow, PDBj:1sow
PDBsum1sow
PubMed
UniProtQ27797|LDH_TOXGO L-lactate dehydrogenase

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