Structure of PDB 1sj2 Chain B

Receptor sequence
>1sj2B (length=717) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
GHMKYPVEGGGNQDWWPNRLNLKVLHQNPAVADPMGAAFDYAAEVATIDV
DALTRDIEEVMTTSQPWWPADYGHYGPLFIRMAWHAAGTYRIHDGRGGAG
GGMQRFAPLNSWPDNASLDKARRLLWPVKKKYGKKLSWADLIVFAGNCAL
ESMGFKTFGFGFGRVDQWEPDEVYWGKEATWLGDERYSGKRDLENPLAAV
QMGLIYVNPEGPNGNPDPMAAAVDIRETFRRMAMNDVETAALIVGGHTFG
KTHGAGPADLVGPEPEAAPLEQMGLGWKSSYGTGTGKDAITSGIEVVWTN
TPTKWDNSFLEILYGYEWELTKSPAGAWQYTAKDGAGAGTIPDPFGGPGR
SPTMLATDLSLRVDPIYERITRRWLEHPEELADEFAKAWYKLIHRDMGPV
ARYLGPLVPKQTLLWQDPVPAVSHDLVGEAEIASLKSQIRASGLTVSQLV
STAWAAASSFRGSDKRGGANGGRIRLQPQVGWEVNDPDGDLRKVIRTLEE
IQESFNSAAPGNIKVSFADLVVLGGCAAIEKAAKAAGHNITVPFTPGRTD
ASQEQTDVESFAVLEPKADGFRNYLGKGNPLPAEYMLLDKANLLTLSAPE
MTVLVGGLRVLGANYKRLPLGVFTEASESLTNDFFVNLLDMGITWEPSPA
DDGTYQGKDGSGKVKWTGSRVDLVFGSNSELRALVEVYGADDAQPKFVQD
FVAAWDKVMNLDRFDVR
3D structure
PDB1sj2 Crystal Structure of Mycobacterium tuberculosis Catalase-Peroxidase.
ChainB
Resolution2.41 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) R104 H108 H270 W321 D381
Catalytic site (residue number reindexed from 1) R81 H85 H247 W298 D358
Enzyme Commision number 1.11.1.21: catalase peroxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM B P100 L101 I103 R104 W107 F252 L265 I266 G269 H270 K274 T275 H276 T314 S315 W321 W412 P77 L78 I80 R81 W84 F229 L242 I243 G246 H247 K251 T252 H253 T291 S292 W298 W389
Gene Ontology
Molecular Function
GO:0004096 catalase activity
GO:0004601 peroxidase activity
GO:0005515 protein binding
GO:0016677 oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0070402 NADPH binding
GO:0070404 NADH binding
Biological Process
GO:0006979 response to oxidative stress
GO:0042744 hydrogen peroxide catabolic process
GO:0045739 positive regulation of DNA repair
GO:0046677 response to antibiotic
GO:0070301 cellular response to hydrogen peroxide
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005576 extracellular region
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1sj2, PDBe:1sj2, PDBj:1sj2
PDBsum1sj2
PubMed15231843
UniProtP9WIE5|KATG_MYCTU Catalase-peroxidase (Gene Name=katG)

[Back to BioLiP]