Structure of PDB 1shj Chain B

Receptor sequence
>1shjB (length=209) Species: 9606 (Homo sapiens) [Search protein sequence]
VPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSL
GFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKD
GVTPIKDLTAHFRGARCKTLLEKPKLFFIQACRGPRYKIPVEADFLFAYS
TVPGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESKQIPCVVSM
LTKELYFSQ
3D structure
PDB1shj Discovery of an allosteric site in the caspases
ChainB
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G85 V86 H144 G145 C186
Catalytic site (residue number reindexed from 1) G31 V32 H90 G91 C132
Enzyme Commision number 3.4.22.60: caspase-7.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NXN B I159 Y211 I213 P214 F221 Y223 C290 V292 I105 Y137 I139 P140 F147 Y149 C196 V198
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1shj, PDBe:1shj, PDBj:1shj
PDBsum1shj
PubMed15314233
UniProtP55210|CASP7_HUMAN Caspase-7 (Gene Name=CASP7)

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